We develop and build new mass spectrometric tools to advance our research. One recent development is a A Novel High‐Capacity Ion Trap‐Quadrupole Tandem Mass Spectrometer constructed in collaboration between our laboratory and Brian Chait’s laboratory at the Rockefeller University. This mass spectrometer was built as a prove of the principle for increasing the efficiency of linked scan analysis by 100-1000 fold.
Based on this prototype instrument, we currently construct and build a fully functional model of such a tandem mass spectrometer here at the UCSF. When build, this new tool will be indispensable for or detecting modification sites on the proteins and profiling their abundances with unprecedented speed and sensitivity.